"The leopard cannot change his spots" is just a figure of speech.

“豹子改变不了身上的斑点”是个比喻，指江山易改本性难移。

《柯林斯英汉双解大词典》

We cannot change the past.

我们无法改变过去。

《新英汉大辞典》

Books cannot change the world, but people change the world by changing themselves through reading.

书本不能改变世界，但是人们通过阅读改变他们自己来改变世界。

youdao

Our genetics cannot change this quickly in order to explain the increase in incidence."

VOA: standard.2010.08.09

It means understanding that certain things I cannot change and certain things I can and ought to change.

它意味着理解有些事,我无法改变，有些事我能而且应该去改变。

哈佛公开课 - 幸福课课程节选

We cannot change it.

不能改变它。

哈佛公开课 - 幸福课课程节选

However well he fills the new job, the central bank alone cannot change things much.

ECONOMIST: Russia's central bank

But now we, too, must ignore the voices who tell us that the world cannot change.

CENTERFORSECURITYPOLICY: ��A World without Nuclear Weapons��

If England cannot change dates, then Sri Lanka may offer to send a weakened squad.

BBC: Sri Lanka put IPL above England